Focuses on a group of toddlers, most prominently Tommy, Chuckie, Phil, Lil, and Angelica, and their day-to-day lives, usually involving common life experiences that become adventures in the babies' imaginations. Adults in the series are almost always unaware of what the children are up to; however, this only provides more room for the babies to explore and discover their surroundings.

Cast

Elizabeth Daily

Elizabeth Daily

Tommy Pickles (voice)

Kath Soucie

Kath Soucie

Phil DeVille / Lil DeVille (voice)

Cheryl Chase

Cheryl Chase

Angelica Pickles (voice)

Dionne Quan

Dionne Quan

Kimi Finster (voice)

Tara Strong

Tara Strong

Dil Pickles (voice)

Joe Alaskey

Joe Alaskey

Grandpa Lou Pickles (voice)

Melanie Chartoff

Melanie Chartoff

Didi Pickles (voice)

Tress MacNeille

Tress MacNeille

Charlotte Pickles (voice)

Jack Riley

Jack Riley

Stu Pickles (voice)

Cree Summer

Cree Summer

Susie Carmichael (voice)

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